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Endocrine Abstracts

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ea0090ep747 | Pituitary and Neuroendocrinology | ECE2023

Immune landscape of peripheral blood mononuclear cells in patients with Cushing’s syndrome and mild autonomous cortisol secretion

Bauerle Ariane , Nowotny Hanna F , Doll Natalie , Zopp Stephanie , Nowak Elisabeth , Vogel Frederick , Gottschlich Adrian , Seiter Thomas Marchant , Reisch Nicole , Rothenfuszer Simon , Matthias Kroiss , Braun Leah , Reincke Martin

Background: Endogenous Cushing’s syndrome (CS) is associated with increased susceptibility to infections and mortality. Previously reported effects of hypercortisolism on immune function include a reduced CD4+/CD8+ ratio with a shift towards IL4+T helper cells (Th2), suppressed NK-cell cytotoxic activity as well as a low-grade inflammatory profile.Aim: This cross-sectional single center study aims to compare immune phenotype in patients with overt C...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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